The new method of pulp regeneration by using stem cells
American scientists have found a new way of pulp tissue regeneration.
According to the recent research of scientists from Tufts University School of Dental Medicine (TUSDM), collagen-based biomaterial enriched with stem cells can be used for activation of pulp regeneration. This method was successfully tested on animals.
For this experiment the researchers used a mix of pulp tissue, gelatin methacrylate (collagen-based material of low cost), and endothelial cells. Then, they placed this mix into sterilized roots of previously extracted tooth. The researches implanted the roots in a rodent animal for eight weeks.
In just four weeks the scientists observed intensified cell growth and the formation of blood vessels. After eight weeks they observed pulp chamber filled with pulp-like tissue. They also noticed erythrocytes in blood vessels and strong adhesion of new tissue to dentin. The team found no inflammation at the side of implantation, which proves the biocompatibility of gelatin methacrylate.
Owing to this study, the team of scientists has found the new perspective way of pulp tissue regeneration. Nevertheless, scientists mentioned that this study did not cover nerve formation in regenerated pulp tissue and additional safety and efficacy studies are necessary.