A biogenic preparation based on peptides will make it possible to treat teeth without a dentist
American scientists from the University of Washington have developed a technology for remineralization of enamel with the help of a biogenic drug based on peptides. The researchers used for this purpose the essence of amelogenin, a protein that plays a key role in the formation of tooth enamel. Peptides derived from amelogenin are the main active component in the new technology.
It is not superfluous to recall that scientists learned about the role of amelogenin in the formation of enamel relatively recently - in 2011.
"These peptides are proven to form on the surface of the teeth and bind calcium and phosphate ions," said Denise Usesoy, co-author of the study.
In natural conditions, the enamel is produced under the influence of ameloblast cells. They excrete the proteins that form the enamel before the tooth is cut from the gum. When the tooth is fully formed, ameloblasts die. In this case, the loss of tooth enamel is observed throughout the life of a person.
In the process of research, scientists compared the action of peptides with fluorine. The developed preparation was applied to the teeth with the initial stage of caries. As a result, a new layer of remineralized enamel was formed in place of the destroyed tissues, firmly connected with the lower layers.
The new product after each use formed a fairly thick layer of enamel in 10-15 10 microns.
In this case, fluoride applied to the same carious lesion did not have a similar effect.
The approach based on peptide remineralization, lays the foundation for the future development of biomimetic products and the solution of important problems in dentistry. After the completion of the development of a new product can be used in dental practice - in solutions and composites, as well as at home - in biomimetic toothpaste, gels. This can be a safe alternative to existing methods of dental treatment. In some cases, the peptide substance can also be used instead of filling the teeth.
This technology will allow people to restore and strengthen tooth enamel daily in the framework of preventive and curative procedures. It is expected that it will be safe for adults and children.
New biogenic dental products can theoretically restore teeth and cure tooth decay without today's costly and unpleasant procedures. "Preparations that support the peptide will be simple and will be introduced into over-the-counter or clinical products," said lead author of the study, Professor Mehmet Sarikaya.